Research group of Jörg Großhans

Institut für Entwicklungsbiochemie
Georg-August-Universität Göttingen











  1. Before 2000

  2. Between 2000-2005

  3. Between 2006-2010

  4. Between 2011-2015

  5. Before 2010

  6. Dissertations

D Kong, F Wolf, J Großhans. Optochemical control of cell contractility at single cell resolution during tissue morphogenesis. bioRxiv 255372. link

B Liu, Hw Sung, I Gregor, A Müller, J Großhans. PpV/PP-6 regulates cell cycle remodelling during mid-blastula transition by destabilizing Twine/Cdc25. bioRxiv 172379 link

A Schmidt, J Großhans. Dynamics of cortical domains in early Drosophila development, J Cell Sci 131 (2018) jcs212795 link free copy

F Kaiser, Z Lv, DM Rodrigues, J Rosenbaum, T Aspelmeiser, J Großhans, K Alim. Mechanical model of nuclei ordering in Drosophila embryos reveals dilution of stochastic forces". Biophys J 114 (2018) 1730-1740 link

R Petrovski, G Krohne, J Großhans. Overexpression of the lamina proteins Lamin and Kugelkern induces specific ultrastructural alterations in the morphology of the nuclear envelope of intestinal stem cells and enterocytes. EJCB 97 (2018) 102-113 link

Z. Lv, J Rosenbaum, T Aspelmeier, J Großhans. A "molecular guillotine" reveals an interphase function of Kinesin-5. J Cell Sci 131 (2018) jcs210583 link free copy

A Schmidt, Z Lv, J Großhans. ELMO and Sponge specify subapical restriction of Canoe and formation of the subapical domain in early Drosophila embryos. Development 145 (2018) dev157909 link free copy commentary

R Petrovski, J Großhans. Expression of lamina proteins suppresses stem cell proliferation. Nucleus 9 (2018) 104-118. link

S Yan, S Acharya, S Gröning, J Großhans. Slam dictates subcellular localization and expression of it own mRNA. Plos Biol 15 (2017) e2003315. link

S Karsch, D Kong, J Großhans, A Janshoff. Single cell defects cause a collective and remote mechanical response in a confluent cell layer. Biophys J 113 (2017) 2601-2608. link

I Gregor, M Spiecker, R Petrovsky, J Großhans, R Ros, J Enderlein. Rapid non-linear image scanning microscopy, Nat Meth 14 (2017) 1087-1089. link

A Prahlad, C Spalthoff, D Kong, J Großhans, MC Göpfert, CF Schmidt. Mechanical properties of a Drosophila larval chordotonal organ. Biophys J 113 (2017) 2796-2804. link

F Winkler, M Kriebel, M Clever, S Gröning, J Großhans. Essential Function of the Serine Hydroxymethyl Transferase (SHMT) Gene During Rapid Syncytial Cell Cycles in Drosophila. G3 7 (2017) 2305–2314. link

B Liu, J Großhans. Link of zygotic genome activation and cell cycle control (review). Meth Mol Biol 1605 (2017) 11-30. PDF link

D Kong, F Wolf, J Großhans. Forces directing germ-band extension in Drosophila embryos (review). Mech Dev 144 (2017) 11-22. link PDF

Z Lv, J Großhans. A radial actin network in apical constriction (preview). Dev Cell 39 (2016) 280-282. link


F Winkler, M Gummalla, L Künneke, Z Lv, A Zippelius, T Aspelmeier, J Großhans. Fluctuation analysis of centrosomes reveals a cortical function of Kinesin-1. Biophysical Journal 109 (2015) 856-868. link PDF

AD Wessel, M Gummalla, J Grosshans, CF Schmidt. The mechanical properties of early Drosophila embryos measured by high-speed video microrheology. Biophysical Journal 108 (2015) 1899-1907. link PDF

C Koke, T Kanesaki, J Großhans, US Schwarz, CM Dunlop. A computational model of nuclear self-organisation in syncytial embryos. J Theor Biol 359 (2014) 92-100. link PDF

Y Zhang, D Kong, L Reichl, N Vogt, F Wolf, J Großhans. The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila. Dev Biol, 390 (2014) 208-220. link PDF

S Acharya, P Laupsien, C Wenzl, S Yan, J Großhans. Function and dynamics of slam in furrow formation in early Drosophila embryo. Dev Biol 386 (2014) 371-384. link PDF

S Bogdan, J Schulz, J Großhans. Formin' cellular structures - physiological roles of Diaphanous (Dia) in actin dynamics. (review). Comm Integ Biol 6 (2013) e27634. link PDF

O Schulz, C Pieper, D Hähnel, M Clever, J Pfaff, RH Kehlenbach, FS Wouters, J Großhans, G Bunt, J Enderlein. Resolution-doubling in fluorescence microscopy with Confocal Spinning-Disk Image Scanning Microscopy. PNAS 110 (2013) 21000-21005. link PDF

S Yan, Z Lv, M Winterhoff, C Wenzl, T Zobel, J Faix, S Bogdan, J Großhans. The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization. J Cell Sci 126 (2013) 1796-1805. link PDF

H.-w Sung, S. Spangenberg, N. Vogt, J Großhans. Number of nuclear divisions in the Drosophila blastoderm controlled by onset of zygotic transcription. Curr Biol 23 (2013) 133-138. link PDF

T Kanesaki, S Hirose, J Großhans, N Fuse. Heterotrimeric G protein signaling governs the cortical stability during apical constriction in Drosophila gastrulation. Mech Dev 130 (2013) 132-142. link PDF

SC Albrecht, A Barata, J Großhans, AA Teleman, TP Dick. In vivo mapping of hydrogen peroxide and oxidaized glutathione reveals chemical and regional specificity of redox homeostasis. Cell metabolism 14 (2011) 819-829. link PDF

T. Kanesaki, C. Edwards, U. Schwarz, J. Großhans. Dynamic ordering of nuclei in syncytial embryos: a quantitative analysis of the role of cytoskeletal networks. Integ Biol 3 (2011) 1112-1119. link PDF


M Polychronidou, J Großhans. Determining nuclear shape: the role of farnesylated nuclear proteins. Nucleus 2 (2011) 1-7. link PDF

M Polychronidou, A Hellwig, J Großhans. The farnesylated nuclear proteins Kugelkern and LaminDm0 affect nuclear morphology by directly interacting with the nuclear membrane. Mol Biol Cell 21 (2010) 2409-2420. link PDF

A Haghayeghi, A Sarac, J Großhans, F Schöck. Pellino is required for Toll pathway activation in Drosophila innate immunity. Mech Dev 127 (2010) 301-307. link PDF

C. Wenzl, S. Yan, P. Laupsien, J. Großhans. Localization of RhoGEF2 during Drosophila cellularization is developmentally controlled by slam. Mech Dev 127 (2010) 371-384. link PDF

A. van Impel, S. Schumacher, M. Draga, H.-M. Herz, J. Großhans, H. A. Müller. Regulation of the RacGTPase pathway by the multi-functional RhoGEF Pebble is essential for mesoderm migration in the Drosophila gastrula. Development 136 (2009) 813-822 link PDF

J. Großhans, A. Brandt. Induction of aging phenotypes. Patent application No. WO 2009/133192 A1.

A. Brandt, G. Krohne, J. Großhans. The farnesylated nuclear proteins Kugelkern and Lamin B promote aging-like phenotypes in Drosophila flies. Aging Cell, 7 (2008) 541-551. link PDF

Y. Wang, P. Janicki, I. Köster, CD. Berger, C. Wenzl, J. Großhans, H. Steinbeisser. Xenopus paraxial protocadherin regulates morphogenesis by antagonizing sprouty. Genes Dev. 22 (2008) 878-883. link PDF

T. Kitzing, A. S. Sahadevan, D. T. Brandt, H. Knieling, S. Hannemann, O. T. Fakler, J. Großhans, R. Grosse. Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev. 21 (2007) 1478-1483. PDF

P. Gawlinski, R. Nikolay,C. Goursot, S. Lawo, B. Chaurasia, H.-M. Herz, Y. Kußler-Schneider, T. Ruppert, M. Mayer,J. Großhans*. The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of Cyclins. EMBO rep. 8 (2007) 490-496. PDF

A. Brandt, F. Papagiannouli, N. Wagner, M. Wilsch-Bräuninger, M. Braun, E. E. Furlong, S. Loserth, C. Wenzl, F. Pilot, N. Vogt, T. Lecuit, G. Krohne, J. Großhans. Developmental control of nuclear size and shape by kugelkern and kurzkern. Curr. Biol. 16 (2006) 543--552. PDF N&V


J. Großhans*, C. Wenzl, H.-M. Herz, S. Bartoszewski, F. Schnorrer, N. Vogt, H. Schwarz, A. Müller. RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation. Development 132 (2005) 1009-1020. PDF

S. Bartoszewski, S. Luschnig, I. Desjeux, J. Großhans, and C. Nüsslein-Volhard. Drosophila p24 homologues eclair and baiser are necessary for the activity of the maternally expressed TKV receptor during early embryogenesis. Mech. Dev. 121 (2004) 1259-1273.

J. Großhans*, A. Müller, and E. Wieschaus. Control of cleavage cycles in Drosophila embryos by frühstart. Dev. Cell 5 (2003) 285-294. PDF

N. Q. Fernandez, J. Großhans, J. S. Goltz, and D. Stein. Redundant regulatory determinants mediate Drosophila dorsal group dependent degradation of Cactus. Development 128 (2001) 2963-2974. PDF

S. Bacher, J. Großhans, W. Dröge, and L. Schmitz. The Drosophila proteins Pelle and Tube induce JNK/AP-1 activity in mammalian cells. FEBS Letters 497 (2001) 153-158. PDF

J. Großhans* and E. Wieschaus. A genetic link between morphogenesis and cell division during formation of the ventral furrow in Dorsophila. Cell 101 (2000) 523-531. PDF

Before 2000

J. Großhans*, F. Schnorrer, and C. Nüsslein-Volhard. Oligomerisation of Tube and Pelle leads to nuclear localisation of Dorsal. Mech. Devel. 81 (1999) 139-150. PDF

J. Großhans. Die Regulation der Kernlokalisierung des Morphogens Dorsal in Drosophila Embryonen. Dissertation. Universität Tübingen, FRG 1996.

J. Großhans*, A. Bergmann, P. Haffter, and C. Nüsslein-Volhard. Activtion of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo. Nature 372 (1994) 563-566. PDF N&V

J. Großhans and R. Wolfenden. Transition-state discrimination by adenosine deaminase from Aspergillus oryzae, Biochem. Biophy. Acta 1161 (1993) 28-32. PDF

F. Deissenrieder and J. Großhans. Computerprogramme Mathematik und Physik. Software mit Begleitbuch (two editions). Winklers Verlag, Gebr. Grimm, Darmstadt, FRG 1987, 1989.

J. Großhans. Curfit: Ein Programm zur Auswertung von Meßdaten für den Apple Computer. MS microsystems GmbH (Inh. H. Parsche), Garching, FRG, 1986.