e-mail:
jgrossh@gwdg.de |
Publications:
Before 2000
Between 2000-2005
Between 2006-2010
Between 2011-2015
Recent publications
Dissertations
B Liu, Hw Sung, I Gregor, A Müller, J Großhans. PpV/PP-6 regulates cell cycle remodelling
during mid-blastula transition by destabilizing Twine/Cdc25. bioRxiv 172379
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B. Liu, J. Großhans. The role of dNTP metabolites in control of the embryonic cell cycle.
Cell Cycle (2019)
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D. Kong, Z. Lv, M. Häring, B. Lin, F. Wolf, J. Großhans In vivo optochemical control of cell
contractility at single cell resolution by Ca2+-mediated light-activation of myosin (CaLM).
EMBO rep (2019).
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FA. Mann, Z. Lv, J. Großhans, F. Opazo, S. Kruss. Nanobody conjugated nanotubes for targeted
near-infrared in vivo imaging and sensing. Ange Chem Int Ed (2019).
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B. Liu, HW Sung, J. Großhans. Multiple functions of the essential gene PpV in
Drosophila early development. G3 (2019).
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B Liu*, F Winkler*, M Herde, CP Witte, J Grosshans. A link between deoxyribonucleotide metabolites
and embryonic cell cycle control. Curr Biol 29 (2019) 1187-1192.
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S Yan, J Großhans.Localization and translation control of slam in Drosophila cellularization, FLY (2018).
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A Schmidt, J Großhans. Dynamics of cortical domains in early Drosophila development, J Cell Sci 131 (2018) jcs212795
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F Kaiser, Z Lv, DM Rodrigues, J Rosenbaum, T Aspelmeiser, J Großhans, K Alim. Mechanical model of nuclei
ordering in Drosophila embryos reveals dilution of stochastic forces". Biophys J 114 (2018) 1730-1740
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R Petrovski, G Krohne, J Großhans. Overexpression of the lamina proteins Lamin and Kugelkern induces
specific ultrastructural alterations in the morphology of the nuclear envelope of intestinal
stem cells and enterocytes. EJCB 97 (2018) 102-113
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Z. Lv, J Rosenbaum, T Aspelmeier, J Großhans. A "molecular guillotine" reveals an interphase
function of Kinesin-5. J Cell Sci 131 (2018) jcs210583
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A Schmidt*, Z Lv*, J Großhans. ELMO and Sponge specify subapical restriction of Canoe and formation
of the subapical domain in early Drosophila embryos. Development 145 (2018) dev157909
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R Petrovski, J Großhans. Expression of lamina proteins suppresses stem cell proliferation.
Nucleus 9 (2018) 104-118.
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S Yan, S Acharya, S Gröning, J Großhans.
Slam dictates subcellular localization and expression of it own mRNA. Plos Biol 15 (2017) e2003315.
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S Karsch, D Kong, J Großhans, A Janshoff. Single cell defects cause a collective and remote
mechanical response in a confluent cell layer. Biophys J 113 (2017) 2601-2608.
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I Gregor, M Spiecker, R Petrovsky, J Großhans, R Ros, J Enderlein. Rapid non-linear image
scanning microscopy, Nat Meth 14 (2017) 1087-1089.
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A Prahlad, C Spalthoff, D Kong, J Großhans, MC Göpfert, CF Schmidt.
Mechanical properties of a Drosophila larval chordotonal organ. Biophys J 113 (2017) 2796-2804.
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| F Winkler, M Kriebel, M Clever, S Gröning, J Großhans.
Essential Function of the Serine Hydroxymethyl Transferase (SHMT) Gene During Rapid Syncytial
Cell Cycles in Drosophila. G3 7 (2017) 2305–2314.
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B Liu, J Großhans. Link of zygotic genome activation and cell cycle control (review).
Meth Mol Biol 1605 (2017) 11-30.
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D Kong, F Wolf, J Großhans.
Forces directing germ-band extension in Drosophila embryos (review).
Mech Dev 144 (2017) 11-22.
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Z Lv, J Großhans. A radial actin network in apical constriction (preview).
Dev Cell 39 (2016) 280-282.
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2011-2015
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F Winkler, M Gummalla, L Künneke, Z Lv, A Zippelius, T Aspelmeier, J Großhans.
Fluctuation analysis of centrosomes reveals a cortical function of Kinesin-1.
Biophysical Journal 109 (2015) 856-868.
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AD Wessel, M Gummalla, J Grosshans, CF Schmidt. The mechanical properties of early
Drosophila embryos measured by high-speed video microrheology.
Biophysical Journal 108 (2015) 1899-1907.
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C Koke, T Kanesaki, J Großhans, US Schwarz, CM Dunlop. A computational model
of nuclear self-organisation in syncytial embryos.
J Theor Biol 359 (2014) 92-100.
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Y Zhang, D Kong, L Reichl, N Vogt, F Wolf, J Großhans. The glucosyltransferase
Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression
and is required for gastrulation movements in Drosophila.
Dev Biol, 390 (2014) 208-220.
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S Acharya, P Laupsien, C Wenzl, S Yan, J Großhans. Function and dynamics of
slam in furrow formation in early Drosophila embryo.
Dev Biol 386 (2014) 371-384.
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S Bogdan, J Schulz, J Großhans. Formin' cellular structures - physiological
roles of Diaphanous (Dia) in actin dynamics. (review).
Comm Integ Biol 6 (2013) e27634.
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O Schulz, C Pieper, D Hähnel, M Clever, J Pfaff,
RH Kehlenbach, FS Wouters, J Großhans, G Bunt, J Enderlein.
Resolution-doubling in fluorescence microscopy with Confocal Spinning-Disk Image
Scanning Microscopy.
PNAS 110 (2013) 21000-21005.
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S Yan, Z Lv, M Winterhoff, C Wenzl, T Zobel, J Faix, S Bogdan, J Großhans.
The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane
stabilization and compartmentalization.
J Cell Sci 126 (2013) 1796-1805.
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H.-w Sung, S. Spangenberg, N. Vogt, J Großhans. Number of nuclear divisions
in the Drosophila blastoderm controlled by onset of zygotic transcription.
Curr Biol 23 (2013) 133-138.
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T Kanesaki, S Hirose, J Großhans, N Fuse. Heterotrimeric G protein signaling
governs the cortical stability during apical constriction in Drosophila
gastrulation.
Mech Dev 130 (2013) 132-142.
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SC Albrecht, A Barata, J Großhans, AA Teleman, TP Dick. In vivo mapping
of hydrogen peroxide and oxidaized glutathione reveals chemical and regional
specificity of redox homeostasis.
Cell metabolism 14 (2011) 819-829.
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T. Kanesaki, C. Edwards, U. Schwarz, J. Großhans. Dynamic ordering of
nuclei in syncytial embryos: a quantitative analysis of the role of
cytoskeletal networks. Integ Biol 3 (2011) 1112-1119.
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2006-2010
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M Polychronidou, J Großhans. Determining nuclear shape: the role
of farnesylated nuclear proteins.
Nucleus 2 (2011) 1-7.
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M Polychronidou, A Hellwig, J Großhans. The farnesylated
nuclear proteins Kugelkern and LaminDm0 affect nuclear morphology by
directly interacting with the nuclear membrane.
Mol Biol Cell 21 (2010) 2409-2420.
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A Haghayeghi, A Sarac, J Großhans, F Schöck. Pellino is required for
Toll pathway activation in Drosophila innate immunity.
Mech Dev 127 (2010) 301-307.
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C. Wenzl, S. Yan, P. Laupsien, J. Großhans. Localization of RhoGEF2 during
Drosophila cellularization is developmentally controlled by slam.
Mech Dev 127 (2010) 371-384.
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A. van Impel, S. Schumacher, M. Draga, H.-M.
Herz, J. Großhans, H. A. Müller.
Regulation of the RacGTPase pathway by the multi-functional RhoGEF Pebble is
essential for mesoderm migration in the Drosophila gastrula.
Development 136 (2009) 813-822
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J. Großhans, A. Brandt. Induction of
aging phenotypes. Patent application No. WO 2009/133192 A1.
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A. Brandt, G. Krohne, J. Großhans.
The farnesylated nuclear proteins Kugelkern
and Lamin B promote aging-like phenotypes in Drosophila flies.
Aging Cell, 7 (2008) 541-551.
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Y. Wang, P. Janicki, I. Köster, CD. Berger,
C. Wenzl, J. Großhans,
H. Steinbeisser. Xenopus paraxial protocadherin regulates morphogenesis by
antagonizing sprouty. Genes Dev. 22 (2008) 878-883.
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T. Kitzing, A. S. Sahadevan, D. T. Brandt, H. Knieling, S. Hannemann, O. T.
Fakler, J. Großhans, R. Grosse.
Positive feedback between Dia1, LARG, and
RhoA regulates cell morphology and invasion. Genes Dev. 21 (2007) 1478-1483.
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P. Gawlinski, R. Nikolay,C. Goursot, S. Lawo, B. Chaurasia, H.-M. Herz, Y.
Kußler-Schneider, T. Ruppert, M. Mayer,J.
Großhans*. The Drosophila mitotic
inhibitor Frühstart specifically binds to the hydrophobic patch of Cyclins.
EMBO rep. 8 (2007) 490-496.
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A. Brandt, F. Papagiannouli, N. Wagner, M. Wilsch-Bräuninger, M. Braun, E. E.
Furlong, S. Loserth, C. Wenzl, F. Pilot, N. Vogt, T. Lecuit,
G. Krohne, J. Großhans.
Developmental control of nuclear size and shape by kugelkern and kurzkern.
Curr. Biol. 16 (2006) 543--552.
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2000-2005
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J. Großhans*, C. Wenzl, H.-M. Herz,
S. Bartoszewski, F. Schnorrer, N. Vogt,
H. Schwarz, A. Müller. RhoGEF2 and the formin Dia control the formation of the
furrow canal by directed actin assembly during Drosophila cellularisation.
Development 132 (2005) 1009-1020. PDF
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S. Bartoszewski, S. Luschnig, I. Desjeux, J. Großhans, and
C. Nüsslein-Volhard. Drosophila
p24 homologues eclair and baiser are necessary for the activity of the maternally expressed
TKV receptor during early embryogenesis. Mech. Dev. 121 (2004) 1259-1273.
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J. Großhans*, A. Müller, and
E. Wieschaus. Control of cleavage cycles in Drosophila
embryos by frühstart. Dev. Cell 5 (2003) 285-294.
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N. Q. Fernandez, J. Großhans,
J. S. Goltz, and D. Stein. Redundant
regulatory determinants mediate Drosophila dorsal group dependent degradation
of Cactus. Development 128 (2001) 2963-2974. PDF
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S. Bacher, J. Großhans, W. Dröge,
and L. Schmitz. The Drosophila proteins
Pelle and Tube induce JNK/AP-1 activity in mammalian cells.
FEBS Letters 497 (2001) 153-158. PDF
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J. Großhans* and E. Wieschaus.
A genetic link between morphogenesis and cell
division during formation of the ventral furrow in Dorsophila. Cell 101 (2000) 523-531.
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Before 2000
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J. Großhans*, F. Schnorrer,
and C. Nüsslein-Volhard. Oligomerisation of Tube
and Pelle leads to nuclear localisation of Dorsal. Mech. Devel. 81 (1999) 139-150.
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J. Großhans. Die Regulation der Kernlokalisierung des Morphogens Dorsal
in Drosophila Embryonen. Dissertation. Universität Tübingen, FRG 1996.
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J. Großhans*, A. Bergmann,
P. Haffter, and C. Nüsslein-Volhard. Activtion
of the kinase Pelle by Tube in the dorsoventral signal transduction pathway
of Drosophila embryo. Nature 372 (1994) 563-566.
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J. Großhans and R. Wolfenden.
Transition-state discrimination by adenosine deaminase
from Aspergillus oryzae, Biochem. Biophy. Acta 1161 (1993) 28-32.
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F. Deissenrieder and J. Großhans. Computerprogramme Mathematik und Physik.
Software mit Begleitbuch (two editions). Winklers Verlag,
Gebr. Grimm, Darmstadt, FRG 1987, 1989.
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J. Großhans. Curfit: Ein Programm zur Auswertung von
Meßdaten für den Apple Computer.
MS microsystems GmbH (Inh. H. Parsche), Garching, FRG, 1986.
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