Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology
Dr. Ralf Heinrich
Dept. of Cellular Neurobiology
Schwann-Schleiden Research Center
Julia-Lermontova-Weg 3
37077 Göttingen
Phone: +49(0)551 / 39177958
Fax: +49(0)551 / 39177952
E-mail: rheinri1@gwdg.de
Hahn N., Heinrich R. Neuroligine, synaptische Regulation und Sozialverhalten von Mensch und Fliege. Biospektrum 21: 476-479, 2015.
Heinrich R. Mechanical communication: producing sound and substrate vibrations. In: The Insects: Structure, Functions and Genetics Editors: R. F. Chapman, S. J. Simpson, S. E. Douglas, E. Bernays. Cambridge University Press, pp. 824-856, 2012.
Heinrich R., Ganter G.K. Nitric oxide/cyclic GMP signaling and insect behavior. In: Nitric Oxide Editors: Bruno Tota and Barry Trimmer; Adv Exp Biol 1:107-127, 2007
Winkler M., Deubzer H.E., Hoch M., Witt O., Heinrich R. Elektronenmikroskopische Untersuchung von Neuroblastomzellen nach Kultivierung auf lumoxTM multiwell Platten. Greiner Bio-ONE, 2007
Heinrich R. Vom Wasserklo des Konrad Lorenz zur Chemie des Verhaltens. Motivationsforschung an kleinen Hirnen. In: Gehirn und Verstehen. Georgia Augusta 2, pp. 68-75, 2003
Heinrich, R., Cromarty, S.I., Hörner, M. and Kravitz, E.A. Intrinsic properties of lobster amine-containing neurosecretory neurons: spontaneous activity and autoinhibition. In: The crustacean nervous system. Editor: K. Wiese; Springer, Berlin Heidelberg, pp. 173-185, 2002
Hörner, M., Heinrich, R. and Kravitz, E.A. Synaptic connectivity of amine-containing neurosecretory cells of lobsters: Inputs to 5HT- and OCT-containing neurons. In: The crustacean nervous system. Editor: K. Wiese; Springer, Berlin Heidelberg, pp. 156-172, 2002
Knorr D.Y., Rodriguez Polo I., Pies H.S., Schwedhelm-Domeyer N., Pauls S., Behr R., Heinrich R. Human CRLF3 is a neuroprotective EV-3 (Epo) receptor. In review.
Knorr D.Y., Schneider K., Büschgens L., Förster J., Georges N.S., Geurten B.R.H., Heinrich R. Protection of insect neurons by erythropoietin/CRLF3-mediated regulation of pro-apoptotic acetylcholinesterase. In review.
Knorr D.Y., Hartung D., Schneider K., Hintz L., Pies H.S., Heinrich R. Locust hemolymph conveys erythropoietin-like cytoprotection via activation of the cytokine receptor CRLF3. Frontiers in Physiology 12: 648245, 2021
Knorr D.Y., Georges N.S., Pauls S., Heinrich R. Acetylcholinesterase promotes apoptosis in insect neurons. Apoptosis 25: 730-746, 2020
Hahn N., Büschgens L., Schwedhelm-Domeyer N., Bank S., Geurten B.R.H., Neugebauer P., Massih B., Göpfert M.C. Heinrich R. The
orphan cytokine receptor CRLF3 emerged with the origin of the nervous
system and is a neuroprotective erythropoietin receptor in locusts. Frontiers in Molecular Neuroscience 12: 251, 2019
Ostrowski D., Heinrich R. Alternative erythropoietin receptors in the nervous system. Journal of Clinical Medicine 7 (2): 24, 2018
Hahn N., Knorr D.Y., Liebig J., Wüstefeld L., Peters K., Büscher M., Bucher G., Ehrenreich H., Heinrich R. The
insect orthologue of the human orphan cytokine receptor CRLF3 is a
neuroprotective erythropoietin receptor in insects. Frontiers in Molecular Neuroscience 10: 223, 2017
Corthals K. Heukamp A.S., Kossen R., Großhennig I., Hahn N., Göpfert M., Heinrich R., Geurten B.R. Neuroligins Nlg2 and Nlg4 affect social behaviour in Drosophila melanogaster. Frontiers in Psychiatry 8: 113, 2017
Bhavsar M.B., Stumpner A., Heinrich R. Brain regions for sound processing and song release in a small grasshopper. Journal of Insect Physiology 99: 15-24, 2017
Miljus N., Massih B., Weis M.A., Rison J.V., Bonnas C.B., Sillaber I., Ehrenreich H., Geurten B.R.H., Heinrich R. Neuroprotection and endocytosis: erythropoietin receptors in insect nervous systems. Journal of Neurochemistry 141: 63-74, 2017
Versteven M., Vanden Broeck L., Geurten B., Zwarts L.,Decraecker L., Beelen M., Göpfert M.C., Heinrich R., Callaerts P. Hearing regulates Drosophila aggression. Proc Nat Acad Sci USA 114: 1958-1963, 2017
Faghihi F., Moustafa A.A., Heinrich R., Wörgötter F. A computational model of conditioning inspired by Drosophila olfactory system. Neural Networks 87: 96-108, 2017
Bhavsar M.B., Heinrich R., Stumpner A. Multielectrode recordings in insect brains. Neuroscience Communications 1: e1088, 2016
Bhavsar M.B., Heinrich R., Stumpner A. Multielectrode recordings from auditory neurons in the brain of a small grasshopper. Journal of Neuroscience Methods, 256: 63-73, 2015.
Mitkowski M., Dahm L., Heinrich R., Monnheimer M., Gerhardt S., Stegmüller J., Hanisch U.K., Nave K.A., Ehrenreich H. Erythropoietin dampens injury-induced microglial motility. Journal of Cerebral Blood Flow & Metabolism 35:1233-1236, 2015.
Miljus N., Heibeck S., Jarrar M., Micke M., Ostrowski D., Ehrenreich H.. Heinrich R. Erythropoietin-mediated
protection of insect brain neurons involves JAK and STAT but not PI3K
transduction pathways. Neuroscience 258:218-227, 2014.
Hahn N., Geurten B., Gurvich A., Piepenbrock D., Kästner A., Zanini, D., Xing G., Xie W., Göpfert M.C., Ehrenreich H., Heinrich R. Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour. Behavioural Brain Research 252: 450-457, 2013
Kästner A., Grube S., El-Kordi A., Stepniak B., Friedrichs H., Sargin D., Schwitulla J., Begemann M., Giegling I., Miskowiak K., Sperling S., Hannke K., Ramin A., Heinrich R., Gefeller O., Nave K., Rujescu D., Ehrenreich H. Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia. Molecular Medicine 18: 1029-1040, 2012
Heinrich R., Kunst M., Wirmer A. Reproduction-related sound production of grasshoppers regulated by internal state and actual sensory environment. Frontiers in Decision Neuroscience 6: 89, 2012.
Wirmer A., Bradler S., Heinrich R. Homology of insect corpora allata and vertebrate adenohypophysis? Arthropod Structure & Development 41: 409-417, 2012.
Ganter G.K., Desilets J.B., Davis-Knowlton J.A., Panaitiu A.E., Sweezy M., Adams A.M., Fisher E.A., O'Brien J.R.M., Kincaid K.M., Heinrich R. Drosophila female precopulatory behavior is modulated by ecdysteroids. J Insect Physiol 58: 413-419, 2012
Kunst M., Pförtner R., Aschenbrenner K., Heinrich R. Neurochemical architecture of the central complex related to its function in the control of grasshopper acoustic communication. PLoS ONE 6(9): e25613, 2011
Ganter G. K., Panaitiu A. E. , Desilets J., Davis-Heim J., Fisher E. A., Tan L. C. H., Heinrich, R., Buchanan E. B., Brooks K. M., Kenney M. T., Verde M. G., Downey J., Adams A. M. Grenier J. S., Maddula S., Shah P., Kincaid, K. Drosophila male sexual behavior is modulated by the steroid hormone ecdysone. J Insect Physiol 57: 1179-1184, 2011
Ostrowski D., Ehrenreich H., Heinrich R. Erythropoietin promotes survival and regeneration of insect neurons in vivo and in vitro. Neuroscience 188: 95-108, 2011
Johnsson T., Kravitz E. A., Heinrich R. Sound production during agonistic behaviour of male Drosophila melanogaster. Fly 5: 29-38, 2011
Wirmer A., Heinrich R. Nitric oxide/cGMP signaling in the corpora allata of female grasshoppers. J Insect Physiol 57: 94-107, 2011
Farca Luna A. J., Heinrich R., Reischig T. The circadian biology of the marbled crayfish. Frontiers in Bioscience E2(4): 1414-1431, 2010
Wirmer A., Faustmann M., Heinrich R. Reproductive behaviour of female Chorthippus biguttulus grasshoppers. J Insect Physiol 56: 745-753, 2010
Heck C., Kunst M., Härtel K., Hülsmann S., Heinrich R. In vivo labeling and in vitro characterisation of central complex neurons involved in the control of sound production. J Neuroscience Methods 183: 202-212, 2009
Gocht D., Wagner S., Heinrich R. Recognition, presence and survival of locust central nervous glia in situ and in vitro. Microscopy Research and Technique 72: 385-397, 2009
Farca Luna A.J., Hurtado-Zavala J.I., Heinrich R. Circadian regulation of agonistic behavior in groups of parthenogenetic marbled crayfish. Journal of Biological Rhythms 24: 64-72, 2009
Weinrich A., Kunst M., Wirmer A., Holstein G.R., Heinrich R. Suppression of grasshopper sound production by nitric oxide-releasing neurons of the central complex. J Comp Physiol A 194: 763-776, 2008
Deubzer H.E., Ehemann V., Westermann F., Heinrich R., Mechtersheimer G., Kulozik A.E., Schwab M., Witt O. Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin, suppresses the phenotype of neuroblastoma cells. Int J Cancer 122:1891-900, 2008
Hoffmann K., Wirmer A., Kunst M., Gocht D., Heinrich R. Muscarinic excitation in grasshopper song control circuits is limited by acetylcholinesterase activity. Zool Sci 24: 1028-1035, 2007
Gocht D., Heinrich R. Postactivation inhibition of spontaneously active neurosecretory neurons in the medicinal leech. J Comp Physiol A 193:347-361, 2007
Wenzel B., Kunst M., Günther C., Ganter G.K., Lakes-Harlan R., Elsner N., Heinrich R. Nitric oxide/cyclic GMP-signaling in the central complex of the grasshopper brain inhibits singing behavior. J Comp Neurol, 488: 129-139, 2005
Heinrich R. Impact of descending brain neurons on the control of stridulation, walking and flight in orthoptera. Microscopy Research and Technique 56: 292-301, 2002
Wenzel B., Elsner N. and Heinrich R. mAChRs in the grasshopper brain mediate excitation by activation of the AC/PKA and the PLC second-messenger pathways. J Neurophysiol 87: 876-888, 2002
Vedenina V.Yu., Heinrich R. and Elsner N. Pharmacological activation of stridulatory behaviour in the grasshopper Chorthippus albomarginatus (Orthoptera: Gomphocerinae). J Evol Biochem Physiol 37: 388-397, 2001
Heinrich R., Wenzel B. and Elsner N. A role for muscarinic
excitation: Control of specific singing behavior by activation of the
adenylate cyclase pathway in the brain of grasshoppers. Proc Nat Acad Sci USA 98: 9919-9923, 2001
Doernberg S.B., Cromarty S.I., Heinrich R., Beltz B.S. and Kravitz E.A. Agonistic behavior in naive juvenile lobsters depleted of serotonin by 5,7-dihydroxytryptamine. J Comp Physiol A 187: 91-103, 2001
Heinrich R., Wenzel B. and Elsner N. Pharmacological brain
stimulation releases elaborate stridulatory behaviour in gomphocerine
grasshoppers – conclusions for the organization of the central
nervous system. J Comp Physiol A 187: 155-169, 2001
Heinrich R., Bräunig P., Walter I., Schneider H. and Kravitz E.A. Aminergic neuron systems of lobsters: Morphology and electrophysiology of octopamine-containing neurosecretory cells. J Comp Physiol A 186: 617-629, 2000
Heinrich R., Cromarty S.I., Hörner M., Edwards D.H. and Kravitz E.A. Autoinhibition of serotonin cells: an intrinsic regulatory mechanism sensitive to the pattern of usage of the cells. Proc Nat Acad Sci USA 96: 2473-2478, 1999
Ganter G.K., Heinrich R., Bunge R.P. and Kravitz E.A. Long-term culture of lobster central ganglia: expression of foreign genes in identified neurons. Biol Bull 197: 40-48, 1999
Lakes-Harlan R., Jacobs K., Heinrich R. Identification of auditory interneurons in situ and in vitro by tracer injection into an afferent neuropil. Naturwissenschaften 85, 240-243, 1998
Heinrich, R., Rozwod, K. and Elsner, N. Neuropharmacological evidence for inhibitory cephalic control mechanisms of stridulatory behaviour in grasshoppers. J Comp Physiol A 183, 389-399, 1998
Heinrich R., Jacobs K., Lakes-Harlan R. Tracing of a neuronal network in the locust by pressure injection of markers into a synaptic neuropil. J Neurosci Meth 80, 81-98, 1998
Heinrich, R., Hedwig, B. and Elsner, N. Cholinergic activation of stridulatory behaviour in the grasshopper Omocestus viridulus L. J Exp Biol 200, 1327-1337, 1997
Hedwig, B. and Heinrich, R. Identified descending brain neurons control different stridulatory motor patterns in an acridid grasshopper. J Comp Physiol A 180, 285-294, 1997
Heinrich, R. and Elsner, N. Central nervous control of hindleg coordination in stridulating grasshoppers. J Comp Physiol A 180, 257-269, 1997
Heinrich, R., Jahto, M. and Kalmring, K. Acoustic
transmission characteristics of the tympanal tracheae of bushcrickets
(Tettigoniidae). II: Comparative studies of the tracheae of seven
species. J Acoust Soc Am 93, 3481-3489, 1993
designed by A. Wirmer