Gerhard H. Braus
Professor of Microbiology and Genetics
- Diploma (Biology), University Freiburg im Breisgau (Germany), 1983.
- Dr.sc.nat., Swiss Fed. Institute of Technology (ETH), Zürich (Switzerland), 1987.
- Biocenter, University Basel (Switzerland), 1987.
- Habilitation (Microbiology), ETH Zürich, 1991.
- Visiting Professor, Dept. of Genetics, University of Georgia, Athens GA (USA), 1992.
- Assoc. Professor of Biochemistry, Univ. Erlangen (Germany) 1993 – 1996.
- Professor of Microbiology (since 2002 Professor of Microbiology & Genetics) at the Georg August University Göttingen (Germany), 1996-
- Visiting Professor, BMS Institute for Functional Genomics, Princeton NJ (USA), 2002.
- Dean of the Biological Faculty of the Georg August University, 2004-2006.
- Dean of Financial Affairs and Vice Dean of the Biological Faculty of the Georg August University, 2006-
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Address:
Dept. of Molecular Microbiology & Genetics
Georg August University
Grisebachstr. 8
37077 Göttingen
Germany
phone: +49-551-39 3771
fax: +49-551-39 3330
e-mail: gbraus@gwdg.de
Further Information:
http://www.gwdg.de/~molmibio |
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The major focus of the laboratory is
on the control of developmental programs, protein turnover, pathogenicity and
the interplay between development and primary and secondary metabolism. Our
models are eukaryotic microorganisms (yeasts and filamentous fungi): (i) We are
interested how light coordinates fungal development with fungal secondary
metabolism and toxin production. (ii) Nedd8 is a ubiquitin-like protein which is
involved in the control of protein turnover. We study the Nedd8-system
including the COP9 signalosome using fungi as model systems. (iii) We are interested in the molecular
control (protein turnover and translation) of adhesion as initial step in
infection and biofilm formation. (iv) We study fungi as models for Parkinson
(yeast), fungi as pathogens of immunocompromised patients (A. fumigatus) and as
plant pathogens (V. longisporum).
Five Selected Recent Publications
Padmanabhan N, Fichtner L, Dickmanns A, Ficner R, Schulz JB, Braus GH (2009) The Yeast HtrA orthologue Ynm3 is a
protease with chaperone activity that aids survival under heat stress.Mol.
Biol. Cell.20, 68-77.
Streckfuss-Bömeke K, Schulze F, Herzog B, , Scholz E, Braus GH
(2009) Degradation of yeast transcription factor Gcn4 requires a C-terminal
nuclear localization signal in the cyclin Pcl5. Euk. Cell.8, 496-510.
Bayram Ö, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon
NJ, Keller NP, Yu JH, Braus GH(2008) VelB/VeA/LaeA complex coordinates light
signal with fungal development and secondary metabolism. Science 320,
1504-1506.
Bayram Ö, Biesemann C, Krappmann S, Galland P, Braus GH (2008) More than a repair enzyme:
Aspergillus nidulans photolyse-like CryA is a regulator of sexual development. Mol. Biol. Cell. 19, 3254-3262.
Valerius O, Kleinschmidt M, , Rachfall N, Schulze F, Marin SL, Hoppert M, Streckfuss-Bömeke K, Fischer
C, Braus GH (2007) The S. cerevisiae homolog of mammalian RACK1, CPC2/ASC1, is
required for FLO11 dependent adhesive growth and dimorphism. Mol. Cell. Proteomics.
6, 1986-1979.
Busch S, Schwier EU, Nahlik K, Bayram Ö, Draht OW, Helmstaedt K,
Krappmann S, Valerius O, Lipscomb WN, Braus GH (2007) An eight-subunit COP9
signalosome with an intact JAMM motif is required for fungal fruit body formation.
Proc. Natl. Acad. Sci. USA. 104, 8125-8130.
Five Reviews/Surveys:
Draht OW, Busch S, Hofmann K, Braus-Stromeyer S, Helmstaedt K, Goldman GH, Braus GH (2007) Amino acid supply of Aspergillus. In: Goldman, Osmani (eds), The Aspergili: Genomics, Medical Aspects, Biotechnology and Research Methods. CRC Press Taylor & Francis Group, Boca Raton FL (USA), Mycology 26, 143-175.
Busch S, Braus GH (2007) How to build a fungal fruit body: from uniform cells to specialized tissue. Mol. Microbiol. 64, 873-876.
Braus GH (2007) Protein-Turnover: Proteinstabilität und Fruchtkörper bei Pilzen. BIOspektrum. 1/07, 12-16.
Braus GH, Pries R, Düvel K, Valerius O (2004) Molecular biology of fungal amino acid biosynthesis regulation. In Kück U (ed), The Mycota II, Genetics and Biotechnology, 2nd edn. Springer Press, Berlin Heidelberg New York Tokyo, pp.239-269.
Irniger S, Braus GH (2003) Controlling transcription by destruction: The regulation of yeast Gcn4p stability. Curr. Genet. 44, 8-18.